Brine Shrimp Lethality of a Glutarimide Alkaloid from Croton sylvaticus Hochst

Authors

  • M. C. KAPINGU1
  • Z. H. MBWAMBO
  • M. J. M.
  • J. J. MAGADULA

Keywords:

Croton sylvaticus, Euphorbiaceae, Julocrotine, Lupeol, Penduliflaworosin, Cytotoxic

Abstract

Cytotoxic properties of pure compounds from the leaves of Croton sylvaticus (Euphorbiaceae) against brine shrimp (Artemia salina) larvae were investigated. A glutarimide alkaloid, julocrotine (1) showed very high cytotoxic activity with a LC50 (95 % CI) value of 0.074 (0.052-0.105) µg/ml when tested in vitro while lupeol (2) and penduliflaworisin (3) were inactive in brine shrimp lethality test. The structures of the isolated compounds were determined by modern spectroscopic methods.

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Published

2018-11-09

Issue

Vol. 8 No. 1 (2005): January-April 2005

Section

Articles

How to Cite

Brine Shrimp Lethality of a Glutarimide Alkaloid from Croton sylvaticus Hochst. (2018). The East and Central African Journal of Pharmaceutical Sciences, 8(1), 3-5. http://jsep.uonbi.ac.ke/ojs/index.php/ecajps/article/view/19