Isolation and structural elucidation of compounds from the non-alkaloidal extract of Nicandra physaloides and the antimicrobial activity of withanicandrin.

Authors

  • N. A. MUKUNGU
  • K. O. ABUGA
  • N. N. MUNGAI
  • K. O. BOSIRE
  • E. W. KARUMI

Keywords:

Nicandra physaloides, withanicandrin, β-sitosterol, stigmasterol, antifungal activity

Abstract

The aerial parts of Nicandra physaloides plant collected from Kenyatta National Hospital grounds were dried and subjected to acid-base extraction and partitioned to obtain alkaloidal and non-alkaloidal extracts. The non-alkaloidal extract yielded three compounds; withanicandrin, β-sitosterol and stigmasterol after column chromatography. Withanicandrin exhibited antifungal activity against Saccharomyces cerevisiae and Candida albicans but lacked antibacterial activity.

References

Downloads

Published

2018-11-21

Issue

Vol. 16 No. 2 (2013): May-August 2013

Section

Articles

How to Cite

Isolation and structural elucidation of compounds from the non-alkaloidal extract of Nicandra physaloides and the antimicrobial activity of withanicandrin. (2018). The East and Central African Journal of Pharmaceutical Sciences, 16(2), 49-53. http://jsep.uonbi.ac.ke/ojs/index.php/ecajps/article/view/153