Brine Shrimp Lethality of Alkaloids from Croton sylvaticus Hoechst

Authors

  • M. C. KAPINGU
  • Z. H. MBWAMBO
  • M. J. MOSHI
  • J. J. MAGADULA

Keywords:

Croton sylvaticus, Euphorbiaceae, julocrotine, lupeol, penduliflaworosin, brine shrimp lethality

Abstract

Three compounds were isolated from the leaves of Croton sylvaticus (Euphorbiaceae) and evaluated for their brine shrimp lethality. Julocrotine, a glutarimide alkaloid, was very toxic in vitro with a LC50 (95% confidence interval) value of 0.074 (0.052-0.105) µg/ml. Lupeol and penduliflaworosin were not toxic. The structures of the isolated compounds were determined by spectroscopic methods.

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Published

2018-11-21

Issue

Vol. 15 No. 2 (2012): May-August 2012

Section

Articles

How to Cite

Brine Shrimp Lethality of Alkaloids from Croton sylvaticus Hoechst. (2018). The East and Central African Journal of Pharmaceutical Sciences, 15(2), 35-37. http://jsep.uonbi.ac.ke/ojs/index.php/ecajps/article/view/137