Vol. 1 No. 1 (2012): African Journal of Pharmacology and Therapeutics
This issue showcases a diverse range of translational biomedical research, molecular epidemiology, and ethnopharmacology, with a strong focus on addressing localized health challenges in East Africa. By bridging clinical genetic research with laboratory-based drug discovery, the included studies offer valuable insights for both public health surveillance and natural medicine.
A significant portion of the issue is dedicated to infectious diseases and host genetics. Researchers highlight critical evolutionary changes in local viral dynamics by tracking a unique genetic reassortment event between seasonal and pandemic influenza strains in Kenya. Complementing this epidemiological work is a clinical study investigating immunogenetics, which explores how specific human leukocyte antigen (HLA) variations influence a woman's susceptibility or resistance to HPV-linked cervical neoplasia.
The issue also heavily features experimental pharmacology and drug discovery from natural sources. Investigative studies evaluate the therapeutic potential of organic extracts from the marine sea urchin Tripneustes gratilla for antimicrobial activity, alongside the in vivo antimalarial efficacy and safety of the medicinal plant Clausena anisata. Finally, the collection addresses experimental methodology, exploring the unpredictable glycemic patterns in chemical-induced diabetic animal models to help researchers improve the reliability of metabolic disease research.
