Wound Healing Effect of Aqueous Extracts of Brucea Antidysenterica and Croton Marcostachyus From Northwest Ethiopia in Albino Mice

Abstract

Back ground: The practice of traditional medicine to treat wound and bleeding disorders in Ethiopia is based on use of numerous herbs. In Ethiopia, the traditional healers use the leaves of Brucea antidysenterica and Croton marcostachyus for wound healing purposes. But no scientific study is reported on the in vivo evaluation of the pharmacological effect of the two selected plants collected locally from Zegie and around Lake Tana monasteries, Northwest Ethiopia.

Objective: The purpose of this study was to evaluate the wound healing effects of Brucea antidysenterica and Croton marcostachyus on a mouse model.

Methods: 50mg/ml and 100mg/ml of Brucea antidysenterica and 50mg/ml and 100mg/ml of Croton marcostachyus leaf aqueous extract solutions were applied on the 1.5cm inflicted wound on the trunk part of the mice of different groups. The degree of wound healing as a percentage was calculated from the wound diameter for each experimental animal.

Result: The aqueous extract 50mg/ml and 100mg/ml of Brucea antidysenterica and Croton marcostachyus achieved a relatively higher degree of wound healing percent compared to the control group. Moreover, the 100mg/ml aqueous leaf extract of Croton marcostachyus and Brucea antidysenterica have shown higher degree of wound healing percent compared to the 50mg/ml concentrations of the two plants.

Conclusion: The current study concluded that the aqueous extracts of Brucea antidysenterica and Croton marcostachyus possess excellent wound healing potential. Hence, the results of the current study support the traditional use of leaf extracts of Croton marcostachyus and Brucea antidysenterica as remedies for wound healing. Further studies are required to isolate the active compounds and determine safety margin of the plant extracts.